Worked with wife, Lella Vignelli. Co-founded Lella and Massimo Vignelli Office of Design and Architecture, 1960 in Milan. Co-founded Unimark International, 1965 in Chicago. Co-founded Vignelli Associates, 1971 in New York. Was head of graphic design and advertising for Knoll International, appointed 1965.

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<ref name=CH>{{cite web |url= |title=Massimo Vignelli |author=Cooper Hewitt, Smithsonian Design Museum |accessdate=5 March 2015 |publisher=Smithsonian Institution}}</ref>