Studied at the Architecture Faculty of Czech Technical University in Prague (1955–1961). Since 1990 Ziegler has taught at the Academy of Arts, Architecture and Design in Prague, and served as chancellor from 2000-2003. He has been active as a typographer, designer, and artist.

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<ref name=CH>{{cite web |url=https://collection.cooperhewitt.org/people/18063467/ |title=Zdenek Ziegler |author=Cooper Hewitt, Smithsonian Design Museum |accessdate=2 February 2026 |publisher=Smithsonian Institution}}</ref>