Margrethe Odgaard attended The Royal Danish Academy of Fine Arts, School of Design in 2005 with additional studies at Rhode Island School of Design. Before setting up her design studio in Copenhagen in 2013, she worked as a printing assistant at The Fabric Workshop and Museum in Philadelphia, USA, followed by seven years as textile designer with the French fashion company EPICE, developing colours and patterns, and overseeing production in India. In addition to running her own studio, she is part of the duo INCLUDED MIDDLE together with furniture designer Chris L. Halstrøm.

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<ref name=CH>{{cite web |url= |title=Margrethe Odgaard |author=Cooper Hewitt, Smithsonian Design Museum |accessdate=28 June 2022 |publisher=Smithsonian Institution}}</ref>